Northwestern University

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Filtering by: Creator Chiu, Andrew Michael Resource type Dissertation Subject Pharmacology

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NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR-Plasticity

Description:

In mature neurons, postsynaptic NMDARs are segregated into two populations, synaptic and extrasynaptic NMDARs, which differ in localization, function, and associated intracellular cascades. These two pools are connected via lateral diffusion, and receptor exchange between them modulates synaptic NMDAR content (NMDAR-plasticity). Here, we identify the phosphorylation of the PDZ-ligand of...

Keyword:

NMDAR, NMDAR-plasticity, Extrasynaptic NMDAR, GluN2B, and PP1

Subject:

Pharmacology and Neurosciences

Creator:

Chiu, Andrew Michael

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_669024 and http://dissertations.umi.com/northwestern:14717