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Filtering by: 2024-06-24 Creator Faith C. Boman Collection Nanoscape: The Journal for Undergraduate Research in Nanoscience Resource type Article

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Characterization of DNA-Functionalized Surfaces by Fluorescence Microscopy

Description:

In the field of clinical diagnostics, biosensors are used to identify genetic disorders by hybridizing a surface-bound DNA sequence with the patient’s DNA. To further improve biosensor design, two nonlinear optical techniques, sum frequency generation (SFG) and second harmonic generation (SHG), were used to probe the orientation, chirality, and surface...

Keyword:

Volume 6

Creator:

Franz M. Geiger, Laurel M. Heckman, and Faith C. Boman

Owner:

Scholarly Digital Publishing

Date Uploaded:

07/23/2018

Date Modified:

07/23/2018

Date Created:

2009

Resource Type:

Article
DNA Probed by Second Harmonic Generation

Description:

Second harmonic generation (SHG), a nonlinear optical tool, was used to characterize DNA bound through a chemical linker to the flat surface of a hemispherical lens. Contact angle measurements were used to guarantee that the chemical linker did not hydrolyze under experimental conditions. SHG experiments followed the effects of salt...

Keyword:

2007

Creator:

Franz M. Geiger, Faith C. Boman, and Allison G. Condie

Owner:

Scholarly Digital Publishing

Date Uploaded:

07/18/2018

Date Modified:

07/18/2018

Date Created:

2007

Resource Type:

Article