Northwestern University

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Filtering by: Creator Sze, Christie C. Resource type Dissertation

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The COMPASS family of histone H3 lysine 4 methyltransferases in transcriptional regulation, stem cell pluripotency, and development

Description:

The evolutionarily conserved COMPASS family of methyltransferases implements histone H3 lysine 4 (H3K4) methylation, an epigenetic mark associated with transcriptional activation. Given the high mutational prevalence of COMPASS subunits across cancers and neurodevelopmental disorders, understanding COMPASS function would lend important insights into disease pathogenesis to facilitate development of effective therapies....

Subject:

Molecular biology

Creator:

Sze, Christie C.

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_744273 and http://dissertations.umi.com/northwestern:15142