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Description:: A central question in neuroscience is how the brain plans movements. Here, I apply neural data analysis and machine learning methods to better understand both eye and arm movement planning, in particular focusing on naturalistic settings. First, I built encoding models to investigate the factors that led to neural activity...
Keyword:: Frontal Eye Field, Generalized Linear Model, Saccade, Neuroscience, Premotor Cortex, and Machine Learning
Subject:: Interdepartmental Neuroscience Program (NUIN)
Creator:: Joshua I Glaser
Owner:: Scholarly Digital Publishing
Date Uploaded:: 02/22/2019
Date Modified:: 02/22/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Description:: Following a stroke, precise, individuated control of single joints is often replaced by highly stereotyped patterns of multi-joint movement, due to a loss of independent joint control, which can negatively impact functional use of the paretic arm. Despite the debilitating nature of this impairment, the precise underlying neural mechanisms remain...
Keyword:: MR imaging, motor control, brainstem, and stroke
Subject:: Interdepartmental Neuroscience Program (NUIN)
Creator:: Meriel Ann Owen
Owner:: Scholarly Digital Publishing
Date Uploaded:: 02/11/2019
Date Modified:: 02/11/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

Description:: Totipotent cells have the highest developmental potential and can only be created by nuclear transfer into oocytes. Identities of maternal factors that can induce this reprogramming remain a mystery. In this report, we demonstrate induction of totipotency on mouse embryonic stem cells by introducing six factors, Hist1h2aa, H3f3b, H1foo, p-Npm2,...
Keyword:: Totipotent, Embryonic, Reprogramming, Stem Cells, Regenerative, and Pluripotent
Subject:: Interdepartmental Neuroscience Program (NUIN)
Creator:: Sanders Oh
Owner:: Scholarly Digital Publishing
Date Uploaded:: 01/25/2019
Date Modified:: 01/25/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

Description:: Psychosocial stress is part of everyday life, and while ubiquitous, stress plays a huge role disease development and treatment. Though the stressor’s intensity, predictability, and frequency (acute vs chronic) are important determinants of disease development, interactions with one’s genetic and epigenetic make-up also play a causal role. Major Depressive Disorder...
Keyword:: coping, HCN, Hyperpolarization activated current, gastrointestinal motilit, stress, and mice
Subject:: Interdepartmental Neuroscience Program (NUIN)
Creator:: Daniel W. Fisher
Owner:: Scholarly Digital Publishing
Date Uploaded:: 01/23/2019
Date Modified:: 01/23/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

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