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Advancing the Delivery and Therapeutic Potential of Biologics with Spherical Nucleic Acids

Description:

The translation of proteins as effective intracellular drug candidates is limited by the challenge of cellular entry and their vulnerability to degradation. To advance their therapeutic potential, cell-impermeable proteins can be readily transformed into protein spherical nucleic acids (ProSNAs) or encapsulated into liposomal spherical nucleic acids (L-SNAs), structures defined by...

Keyword:

Intracellular Delivery, Enzyme, Spherical Nucleic Acid, Cancer Vaccine, Biologic, and Blood-Brain Barrier

Subject:

Chemistry

Creator:

Kusmierz, Caroline Danielle

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

10/07/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15666 and etdadmin_upload_837502