Cancer remains a leading cause of death worldwide, necessitating continued study to explore and unravel its complex etiology. For example, there has been a shift of focus in cancer treatment from surgery and radiotherapy to targeted chemo- and immunotherapies as we gain more knowledge on the hallmarks of cancer (e.g.,...
Oligonucleotides can be used to modulate the regulation of pathological genes that are associated with various diseases. However, due to biological barriers, efficient delivery of oligonucleotides, especially to extrahepatic tissues, remains a challenge. To overcome these barriers, multiple delivery strategies have been developed, ranging from medicinal chemistry to nanotechnology. Nanoparticle-based...