Index Catalog // Arch : Northwestern University Institutional Repository

Description:: This dissertation focuses on the development of quantitative approaches for characterizing endogenous signaling pathways and designing new pathways in mammalian cells. I demonstrate how mathematical descriptions that are formulated to explain gene expression patterns can also serve as a powerful springboard for deeper analyses into the properties and functions of...
Keyword:: macrophage, systems biology, receptor, computational biology, transcription factor, and synthetic biology
Subject:: Bioengineering, Molecular biology, and Immunology
Creator:: Muldoon, Joseph Jacob
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15256 and etdadmin_upload_764084

Description:: Many transcription factors (TFs) regulate oncogenic processes and are therefore desirable targets for drug intervention. However, few TF inhibitors have been developed to date due to a lack of specificity and few TF binding pockets. The Meade Lab has overcome these challenges by using cobalt-based complexes that disrupt Cys2His2 zinc...
Keyword:: cellular delivery, zinc finger, hedgehog pathway, coordination complex, cobalt complex, and transcription factor
Subject:: Nanoscience, Molecular biology, and Chemistry
Creator:: Bajema, Elizabeth Amber
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14453 and etdadmin_upload_626420

Description:: Recent advances in cell-free synthetic biology have spurred the development of in vitro molecular diagnostics that serve as effective alternatives to whole-cell biosensors. However, cell-free sensors for detecting manmade organic water contaminants such as pesticides are sparse, partially because few characterized natural biological sensors can directly detect such pollutants. Here,...
Keyword:: biosensor, TX-TL, atrazine, cell-free, cyanuric acid, metabolism, synthetic biology, and transcription factor
Creator:: Umut Akova, Khalid K. Alam, Michael C. Jewett, Julius B. Lucks, and Adam D. Silverman
Owner:: Adam Silverman
Date Uploaded:: 09/23/2019
Date Modified:: 02/19/2020

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