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Description:: Aging is the greatest known risk factor for Alzheimer’s Disease (AD); however, the molecular mechanisms underlying aging and how it can initiate and or exacerbate AD, is still unknown. Epigenetic regulation has been widely accepted to play an essential role in aging or AD-related processes; however, whether dysregulations of histone...
Keyword:: HDACs, Alzheimer's Disease, Epigenetics, and Aging
Subject:: Neurosciences
Creator:: McClarty, Bryan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 05/31/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_954939 and http://dissertations.umi.com/northwestern:16390

Description:: Aging is the greatest known risk factor for Alzheimer’s Disease (AD); however, the molecular mechanisms underlying aging and how it can initiate and or exacerbate AD, is still unknown. Epigenetic regulation has been widely accepted to play an essential role in aging or AD-related processes; however, whether dysregulations of histone...
Keyword:: HDACs, Alzheimer's Disease, Epigenetics, and Aging
Subject:: Neurosciences
Creator:: McClarty, Bryan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 03/24/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_954939 and http://dissertations.umi.com/northwestern:16390

Description:: Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimer’s disease (AD); however, little is known about the early mechanisms that contribute to this process. To objectively assess protein turnover at early stages of amyloid beta (Aβ) proteotoxicity, we used dynamic metabolic labeling with stable isotopes followed by proteomic...
Keyword:: Synaptic Vesicles, Alzheimer's Disease, Presynapse, Proteomics, and Protein Degradation
Subject:: Neurosciences
Creator:: Hark, Timothy
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15385 and etdadmin_upload_780177

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