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The N-Terminus of Tau in Filament Formation and the Regulation of Axonal Transport: A Perspective on Tau Assembly and Toxicity

Description:

In several neurodegenerative diseases, the microtubule-associated protein tau self-aggregates to form filaments that accumulate in neurons and/or glia, although the relationship between tau aggregation and cell death is a subject of debate. The amino terminus of tau is involved in conformational changes that appear critical for filament formation, hinting at...

Keyword:

filament, axonal transport, kinesin, Alzheimer's disease, and tau

Subject:

Neuroscience Institute Graduate Program

Creator:

Nichole LaPointe

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/06/2018

Date Modified:

09/06/2018

Date Created:

2008-02-21

Resource Type:

Dissertation
The Role of the N-terminus of Tau in Alzheimer's Disease

Description:

The polymerization of the microtubule-associated protein, tau, into insoluble filaments is common to Alzheimer's disease (AD) and in a variety of dementias. The conformational change required for tau to transition from soluble monomers to filamentous AD pathology involves the extreme N-terminus of tau coming into contact with other regions of...

Keyword:

Alzheimer's disease, tangle, N-terminus, frontotemporal dementia, and tau

Subject:

Neuroscience Institute Graduate Program

Creator:

Peleg Moshe Horowitz

Owner:

Scholarly Digital Publishing

Date Uploaded:

05/07/2018

Date Modified:

05/07/2018

Date Created:

2006-11-16

Resource Type:

Dissertation

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The N-Terminus of Tau in Filament Formation and the Regulation of Axonal Transport: A Perspective on Tau Assembly and Toxicity

The Role of the N-terminus of Tau in Alzheimer's Disease

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