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Filtering by: "digitalpublishing@northwestern.edu" Keyword Apoptosis

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A Changing Perspective on Eosinophil Siglec-8 Signaling: Functional Characterization in Humans and Mice

Description:

Eosinophils are major effector cells in diseases including asthma, rhinitis, certain gastrointestinal disorders and atopic dermatitis. Current treatments include mediator antagonists and anti-inflammatory drugs that reduce allergic cell numbers and inhibit mediator release, but they are not fully effective or curative. On their surface, eosinophils selectively express Siglec-8 (sialic acid-binding...

Keyword:

Siglec-8, Eosinophils, Apoptosis, and Signaling

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Daniela Janevska Carroll

Owner:

Scholarly Digital Publishing

Date Uploaded:

01/23/2019

Date Modified:

01/30/2019

Date Created:

2017-01-01

Resource Type:

Dissertation
Bim Regulates Myeloid Cell Homeostasis to Control Systemic Autoimmunity

Description:

The Bcl-2 family is considered the guardian of the mitochondrial apoptotic pathway. While there are numerous endogenous Bcl-2 antagonists that share similar homology, structure, topology, and expression pattern, only the loss of Bim in mice is sufficient to lead to the development of a systemic autoimmunity. Even loss of both...

Keyword:

Apoptosis

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

FuNien Tsai

Owner:

Scholarly Digital Publishing

Date Uploaded:

01/23/2019

Date Modified:

01/23/2019

Date Created:

2017-01-01

Resource Type:

Dissertation

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A Changing Perspective on Eosinophil Siglec-8 Signaling: Functional Characterization in Humans and Mice

Bim Regulates Myeloid Cell Homeostasis to Control Systemic Autoimmunity

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