Northwestern University

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Filtering by: Keyword C9orf72 Keyword nucleocytoplasmic transport

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Uncovering Molecular Mechanisms of C9orf72- and NEK1-related ALS Pathogenesis Using iPSC-Derived Motor Neurons

Description:

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by motor neuron (MN) degeneration and resulting in progressive paralysis and death. ALS is genetically heterogeneous, disease pathophysiology is not completely understood, and there are no effective drug therapies. To develop broadly applicable therapeutics, we examine disease mechanisms in the...

Keyword:

ALS, C9orf72, iPSCs, nucleocytoplasmic transport, NEK1, and microtubules

Subject:

Molecular biology, Cellular biology, and Neurosciences

Creator:

Daley, Elizabeth

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

10/07/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15607 and etdadmin_upload_825395