Northwestern University

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CD81 Partners with CD44 in Promoting Exosome Integrity, Tumor Cell Cluster Formation, and Lung Metastasis in Triple Negative Breast Cancer

Description:

Tumor-initiating cells with reprogramming plasticity are thought to be essential for cancer development and metastatic regeneration in many cancers; however, the molecular mechanisms are not fully understood. We have previously identified that CD44, a breast tumor-initiating cell marker, drives mammosphere self-renewal and multicellular aggregation of circulating tumor cell (CTC) clusters,...

Keyword:

exosomes, CD44, cancer stem cells, extracellular vesicles, CD81, and breast cancer

Subject:

Molecular biology, Biology, and Cellular biology

Creator:

Ramos, Erika Kathryn

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/16/2023

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:16152 and etdadmin_upload_916551