Northwestern University

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Molecular Mechanisms of Orai1 Channel Activation by STIM1

Description:

Store-operated Ca2+ entry through Orai1 channels mediate transcriptional, proliferative, and effector cell programs in many cells and are activated through a unique inside-out mechanism involving binding of the endoplasmic reticulum Ca2+ sensor, STIM1, to cytoplasmic sites on Orai1. Mutations in Orai1 that block channel activation or evoke constitutive channel activity...

Keyword:

Orai1, Gating, STIM1, Channel, CRAC, and Calcium

Subject:

Pharmacology, Biology, and Biophysics

Creator:

Yeung, Priscilla See-Wai

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2018-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_622219 and http://dissertations.umi.com/northwestern:14422