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Topology Inspired Methods for the Design and Analysis of Transcriptomic Time-Series Data in Circadian Biology Research

Description:

Circadian rhythms — physiological, behavioral, and metabolic oscillations with an approximate 24-h period — are controlled by an evolutionarily conserved set of core clock genes operating at the transcriptional and protein level. Entrainable by Zeitgebers (external environmental stimuli such as light, temperature, and food) that modulate time-of-day specific functions, the...

Keyword:

Time-Series Analysis, Biostatistics, Topological Data Analysis, Gene Expression Analysis, Dynamical Systems, Computational Biology, Circadian Rhythms., Circadian Biology, and Differential Rhythm Detection

Creator:

Ness-Cohn, Elan

Owner:

Chris Diaz

Publisher:

Northwestern University

Date Uploaded:

01/20/2022

Date Modified:

01/20/2022

Date Created:

2021-01-07

Resource Type:

Dataset
An Investigation into the Reproducibility of Computational Tools used in Genomics Research

Description:

Recent studies have shown that many high profile studies in biology could not be reproduced, calling into questions the legitimacy of their findings. These reports have the potential to greatly jeopardize the credibility of scientists in the field as well as erode public confidence in the scientific enterprise. Computational research...

Keyword:

Sequencing, Reproducibility, and Computational Biology

Subject:

Bioinformatics and Engineering

Creator:

Liu, Sophia Shou

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_658807 and http://dissertations.umi.com/northwestern:14578

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Topology Inspired Methods for the Design and Analysis of Transcriptomic Time-Series Data in Circadian Biology Research

An Investigation into the Reproducibility of Computational Tools used in Genomics Research

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