Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Evolutionary theory predicts that reproduction entails energetic costs that detract from somatic maintenance, accelerating biological aging. In women, such ‘costs of reproduction’ (CoR) are thought to arise predominantly during pregnancy and lactation, while in men the physiological effects of the steroid hormone testosterone (T) are believed to be a major...
Keyword:: Epigenetic clocks, Tradeoffs, Disposable soma theory, Costs of reproduction, Aging, and DNA methylation
Subject:: Genetics, Evolution & development, and Biology
Creator:: Ryan, Calen Patrick
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_780539 and http://dissertations.umi.com/northwestern:15395

Description:: Uterine leiomyoma (LM), the most common tumor of women, causes severe morbidity. LM cells can be separated into three molecularly and functionally distinct cell populations based on the expression pattern of CD34 and CD49b: stem (LSC, CD34+/CD49b+), intermediate (LIC, CD34+/CD49b-), and differentiated cells (LDC, CD34-/CD49b-). Progesterone via progesterone receptor (PR/PGR)...
Keyword:: RANK/RANKL pathway, Progesterone signaling, Tumor stem cell, DNA methylation, and Uterine leiomyoma
Subject:: Biology
Creator:: Liu, Shimeng
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 01/21/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15024 and etdadmin_upload_722143

Description:: High-dimensional data are becoming increasingly available in various fields as data collection technology advances. Not only are we interested in knowing which variables are relevant to the response and which are not, but also a simpler model with less predictor variables is easier for interpretation and computational purposes. Furthermore, a...
Keyword:: Variable Selection, Iterative Sure Independence Screening, Elastic net, Spike-or-Slab, Medical Expenditure, and DNA methylation
Subject:: Statistics
Creator:: Grace Yoon
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/09/2018
Date Modified:: 01/29/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

Description:: DNA methylation in repetitive elements (RE) suppresses their mobility and maintains genomic stability, and decreases in it are frequently observed in tumor and/or surrogate tissues. Averaging methylation across RE in the genome is widely used to quantify global methylation. Methylation of RE in humans is considered a surrogate for global...
Keyword:: Repetitive elements, Cancer, Machine learning, and DNA methylation
Subject:: Health Sciences Integrated PhD Program
Creator:: Yinan Zheng
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/26/2018
Date Modified:: 04/26/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

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