Northwestern University

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Filtering by: Keyword Enzyme Mechanism Keyword Magnetic Tweezers

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Mechanistic Studies of Type IA and IIA Topoisomerases Using Orthogonal Single-Molecule Techniques

Description:

Topoisomerases are ubiquitous enzymes involved in maintaining the supercoiled state of DNA in the cell. Structural, biophysical, and biochemical studies have provided an overall view of the mechanisms of DNA transformation by these enzymes, but many aspects, particularly their dynamic characteristics, remain poorly understood. Type IA topoisomerases change the topology...

Keyword:

Fluorescence, Enzyme Mechanism, Magnetic Tweezers, Single-Molecule, Topoisomerase, and DNA Topology

Subject:

Interdepartmental Biological Sciences (IBiS) Graduate Program

Creator:

Kathryn Harris Gunn

Owner:

Scholarly Digital Publishing

Date Uploaded:

04/13/2018

Date Modified:

01/28/2019

Date Created:

2017-01-01

Resource Type:

Dissertation