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HEXOKINASE 1 SUBCELLULAR LOCALIZATION REGULATES THE METABOLIC FATE OF GLUCOSE

Description:

The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative pathways, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. HK1 contains an N-terminal domain that permits mitochondrial binding, but its physiologic significance remains unclear. We generated mice lacking the HK1 mitochondrial-binding...

Keyword:

Inflammation, Hexokinase, Macrophage, Subcellular localization, Metabolism, and Mitochondria

Subject:

Biology

Creator:

De Jesus, Adam

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_773389 and http://dissertations.umi.com/northwestern:15348
Human CD99L2 Regulates Leukocyte Transmigration at a Unique Step between those Regulated by PECAM-1 and CD99

Description:

CD99-Like 2 (CD99L2) is a 52 kDa type I glycoprotein expressed on leukocytes and endothelial cells as well as other cell types in mice. It is related to CD99, although it shows only 32% sequence identity. CD99L2 has been shown to play a role in leukocyte extravasation in mice under...

Keyword:

Inflammation, Transmigration, Leukocyte, PECAM, Endothelial Cell, and CD99-like 2

Subject:

Pathology, Molecular biology, and Immunology

Creator:

Rutledge, Nakisha S

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_903372 and http://dissertations.umi.com/northwestern:16098

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HEXOKINASE 1 SUBCELLULAR LOCALIZATION REGULATES THE METABOLIC FATE OF GLUCOSE

Human CD99L2 Regulates Leukocyte Transmigration at a Unique Step between those Regulated by PECAM-1 and CD99

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