Northwestern University

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Uncovering the Origins of the Binding Properties of Spherical Nucleic Acids

Description:

Spherical nucleic acids (SNAs) are a class of structures composed of spherical nanoparticle cores that are densely functionalized with radially oriented, linear DNA. SNAs exhibit properties that are distinct from those of their linear counterparts. These constructs can readily enter cells, evade nuclease degradation, and bind complementary DNA targets with...

Keyword:

Nanoparticles, DNA, Hybridization, Thermodynamics, and Synthesis

Subject:

Chemistry

Creator:

Lam-Kiu Fong

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/30/2019

Date Modified:

09/30/2019

Date Created:

1/1/2018

Resource Type:

Dissertation