Proteins and many other systems are often conceptualized as networks to access analysis methods from the field of network science. Several approaches use molecular dynamics (MD) simulations of proteins to construct networks using correlational statistics. However, in the field of network science, a well-established approach for network construction is solving...
Eosinophils are major effector cells in diseases including asthma, rhinitis, certain gastrointestinal disorders and atopic dermatitis. Current treatments include mediator antagonists and anti-inflammatory drugs that reduce allergic cell numbers and inhibit mediator release, but they are not fully effective or curative. On their surface, eosinophils selectively express Siglec-8 (sialic acid-binding...