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Filtering by: Keyword Sirtuins Resource type Dissertation

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Aberrant acetylation of mitochondrial proteins, due to loss of SIRT3, results in tumor permissive phenotypes and increases breast cancer malignancy risk

Description:

SIRT3 is a mitochondrial-localized, NAD+-dependent deacetylase, tumor suppressor protein that functions to direct mitochondrial energy sensing and antioxidant proteins, increasing the efficiency of energy utilization, providing a redox balanced environment, and preventing aging-related diseases. One SIRT3 deacetylation target is NADP+-dependent isocitrate dehydrogenase 2 (IDH2), a key Krebs Cycle enzyme that...

Keyword:

MnSOD, IDH2, Cancer, and Sirtuins

Subject:

Driskill Graduate Training Program in Life Sciences

Creator:

Xianghui Zou

Owner:

Scholarly Digital Publishing

Date Uploaded:

04/13/2018

Date Modified:

04/13/2018

Date Created:

2017-01-01

Resource Type:

Dissertation