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Insights on the Intracellular Mechanism of Action of the Anticancer and Antiangiogenic Copper Chelator Drug: Ammonium Tetrathiomolybdate (TM)

Description:

The biological antagonism between copper and molybdenum, first observed when cattle developed copper deficiencies after ingesting high levels of plant-born molybdenum, is currently being used in humans to treat two conditions: Wilson's Disease as well as several forms of metastatic cancer. There is surprisingly little known about the interaction of...

Keyword:

biophysics, bioinorganic chemistry, structural chemistry, and inorganic biochemistry

Subject:

Chemistry

Creator:

Hamsell Miguel Alvarez

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/12/2018

Date Modified:

09/12/2018

Date Created:

2008-05-27

Resource Type:

Dissertation
Self assembly and many-body effects at surfaces of biomedical relevance

Description:

I present research in systems of biomedical relevance consisting of agents near or com- prising surfaces using computational approaches. The research topics include formation of bacterial biofilms, behavior of charged species near stacked, like-charged lamellae, and the the conformational behavior of lamellae with strong self-attraction. In chapter 2, I present...

Keyword:

biophysics, soft matter, molecular dynamics, coarse graining , self assembly, and computer simulations

Subject:

Material Science and Engineering

Creator:

Bernard McAlpine Beckerman

Owner:

Scholarly Digital Publishing

Date Uploaded:

02/13/2018

Date Modified:

02/13/2018

Date Created:

2016-01-01

Resource Type:

Dissertation

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Insights on the Intracellular Mechanism of Action of the Anticancer and Antiangiogenic Copper Chelator Drug: Ammonium Tetrathiomolybdate (TM)

Self assembly and many-body effects at surfaces of biomedical relevance

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