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Filtering by: Keyword deep dorsal horn (DDH) neurons Keyword serotonin (5-HT)

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Bursting Deep Dorsal Horn Neurons: Potential Contributor to Muscle Spasms

Description:

Loss of inhibitory control from descending serotonergic (5-HT) fibers deregulates the excitability of spinal motoneurons and interneurons following spinal cord injury (SCI). Exaggerated synaptic activity triggers long-lasting excitatory postsynaptic potentials (long EPSPs) in hyperexcitable motoneurons to ultimately drive muscle spasms at the chronic stage of SCI. Deep dorsal horn (DDH)...

Keyword:

muscle spasms, N-methyl-D-aspartate (NMDA), serotonin (5-HT), spinal cord injury (SCI), deep dorsal horn (DDH) neurons, and zolmitriptan

Subject:

Interdepartmental Neuroscience Program (NUIN)

Creator:

Theeradej Thaweerattanasinp

Owner:

Scholarly Digital Publishing

Date Uploaded:

03/13/2018

Date Modified:

03/13/2018

Date Created:

2017-01-01

Resource Type:

Dissertation