Northwestern University

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Filtering by: Keyword induced pluripotent stem cells Keyword nilotinib Subject Pharmacology

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A Human Induced Pluripotent Stem Cell Model of Nilotinib-Induced Arterial Disease

Description:

Nilotinib is a highly effective tyrosine kinase inhibitor used to treat Chronic Myeloid Leukemia (CML). While nilotinib successfully treats CML, a common and serious side effect is development of nilotinib-induced arterial disease (NAD) even in patients without pre-existing risk factors. This side effect is not seen with imatinib, a CML...

Keyword:

vascular smooth muscle cells, nilotinib, induced pluripotent stem cells, CML, and endothelial cells

Subject:

Pharmacology

Creator:

Pinheiro, Emily

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

08/23/2023

Date Created:

2023-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_1015403 and http://dissertations.umi.com/northwestern:16792