Northwestern University

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The mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation

Description:

The NLRP3 inflammasome is a multi-protein complex that drives sterile and pathogen-dependent inflammation. Activation of the NLRP3 inflammasome occurs in two steps: priming and activation. Priming occurs in response to an inflammatory stimulus, such as LPS. LPS-primed macrophages are subsequently activated by a second stimuli, most of which require K+...

Keyword:

macrophage, mitochondria, immunometabolism, inflammasome, and metabolism

Subject:

Biology

Creator:

Billingham, Leah Katherine

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15953 and etdadmin_upload_882213