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Description:: Cardiovascular disease is a leading cause of morbidity and mortality worldwide. While many therapies have been used to treat vascular disease symptomatically, gene therapy offers a means of treating the molecular dysfunctions driving disease pathogenesis. Unfortunately, gene therapy has achieved only modest therapeutic success in clinical trials due to a...
Keyword:: nuclear import, karyopherins, plasmid, nuclear localization signal, and gene therapy
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Aaron Michael Miller
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/17/2018
Date Modified:: 09/17/2018
Date Created:: 2008-08-01
Resource Type:: Dissertation

Description:: Although non-viral gene therapy has great potential for use in the lung, several problems including inefficient gene transfer and expression and the relative lack of cell-specific targeting have limited its applications. The two approaches that have been used to target genes to desired cell types are through specific ligand-receptor interactions...
Keyword:: nuclear import, SP-C, gene therapy, plasmid, and non-viral
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: James Vincent DeGiulio
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/16/2018
Date Modified:: 08/16/2018
Date Created:: 2007-09-24
Resource Type:: Dissertation

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