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The Multifunctional Role of Substrate-Binding Proteins in Heme Uptake and Antimicrobial Resistance

Description:

Pathogenic bacteria scavenge essential nutrients including metals, amino acids and peptides to survive within the hostile host environment. Bacteria utilize ATP-binding cassette (ABC) transporters, powered by the energy of ATP hydrolysis, to move substrates across cellular membranes. The substrate-binding protein (SBP) shuttles substrate in the periplasm and directs the substrate...

Keyword:

ABC transporters, substrates, peptides, binding proteins, and heme

Subject:

Biology and Biophysics

Creator:

Tanaka, Kari J

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14534 and etdadmin_upload_640137
Using Mass Spectrometry and Self-Assembled Monolayers for Applications in Biochips

Description:

Biochips and high-throughput screening methods are powerful tools for studying biological processes. The combination of peptide arrays and SAMDI mass spectrometry incorporates these tools to study a broad range of biochemical transformations, including enzyme activities, to provide valuable information on substrate recognition and guide the development of diagnostic and therapeutic...

Keyword:

high-throughput screening, enzyme activity, peptides, self-assembled monolayers, chemical biology, and biochips

Subject:

Bioengineering

Creator:

Wood, Sarah Elizabeth

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14669 and etdadmin_upload_662973

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The Multifunctional Role of Substrate-Binding Proteins in Heme Uptake and Antimicrobial Resistance

Using Mass Spectrometry and Self-Assembled Monolayers for Applications in Biochips

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