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Investigating How Membrane Mechanical Properties Affect the Expression, Folding, and Function of a Model Mechanosensitive Channel Protein

Description:

Mechanosensation is an essential behavior for cellular health that depends on the interactions between the plasma membrane and stretch-activated ion channels. To date, a few studies have measured the effect of membrane composition on protein behaviors from folding to function. However, the relationship between membrane mechanical properties and these behaviors...

Keyword:

electrophysiology, mechanobiology, membrane, protein folding, membrane protein, and polymer

Subject:

Biophysics

Creator:

Jacobs, Miranda

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_893855 and http://dissertations.umi.com/northwestern:15990
The Role of Alpha-Synuclein Aggregation in Endoplasmic Reticulum Protein Folding and Homeostasis

Description:

Protein homeostasis, or proteostasis, is essential for preserving all cellular functions and involves a balance of protein synthesis, folding, trafficking, and degradation. A collapse in proteostasis is a common feature of many neurodegenerative disorders that are characterized by the accumulation of insoluble protein aggregates in the brain. Parkinson’s disease (PD)...

Keyword:

induced pluripotent stem cell models, ER stress, protein aggregation, protein folding, and lysosomal dysfunction

Subject:

Molecular biology and Neurosciences

Creator:

Stojkovska, Iva

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/02/2022

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_850723 and http://dissertations.umi.com/northwestern:15793

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Investigating How Membrane Mechanical Properties Affect the Expression, Folding, and Function of a Model Mechanosensitive Channel Protein

The Role of Alpha-Synuclein Aggregation in Endoplasmic Reticulum Protein Folding and Homeostasis

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