Mechanosensation is an essential behavior for cellular health that depends on the interactions between the plasma membrane and stretch-activated ion channels. To date, a few studies have measured the effect of membrane composition on protein behaviors from folding to function. However, the relationship between membrane mechanical properties and these behaviors...
Protein homeostasis, or proteostasis, is essential for preserving all cellular functions and involves a balance of protein synthesis, folding, trafficking, and degradation. A collapse in proteostasis is a common feature of many neurodegenerative disorders that are characterized by the accumulation of insoluble protein aggregates in the brain. Parkinson’s disease (PD)...