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Model-driven elucidation of synthetic and immune signaling mechanisms

Description:

This dissertation focuses on the development of quantitative approaches for characterizing endogenous signaling pathways and designing new pathways in mammalian cells. I demonstrate how mathematical descriptions that are formulated to explain gene expression patterns can also serve as a powerful springboard for deeper analyses into the properties and functions of...

Keyword:

macrophage, systems biology, receptor, computational biology, transcription factor, and synthetic biology

Subject:

Bioengineering, Molecular biology, and Immunology

Creator:

Muldoon, Joseph Jacob

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15256 and etdadmin_upload_764084
A Gli-Targeted Cobalt Complex and Nanoparticle Delivery Agents for Hedgehog Pathway Inhibition

Description:

Many transcription factors (TFs) regulate oncogenic processes and are therefore desirable targets for drug intervention. However, few TF inhibitors have been developed to date due to a lack of specificity and few TF binding pockets. The Meade Lab has overcome these challenges by using cobalt-based complexes that disrupt Cys2His2 zinc...

Keyword:

cellular delivery, zinc finger, hedgehog pathway, coordination complex, cobalt complex, and transcription factor

Subject:

Nanoscience, Molecular biology, and Chemistry

Creator:

Bajema, Elizabeth Amber

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2018-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14453 and etdadmin_upload_626420

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Model-driven elucidation of synthetic and immune signaling mechanisms

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