Patients with sickle cell disease (SCD) experience lifelong struggles with both chronic and acute pain, often requiring medical intervention. Pain can be managed with medications, but dosages must balance the goal of pain mitigation against the risks of tolerance, addiction and other adverse effects. Setting appropriate dosages requires knowledge of...
A longstanding goal of synthetic biology has been the programmable control of cellular functions. Central to this is the creation of versatile regulatory toolsets that allow for programmable control of gene expression. Of the many regulatory molecules available, RNA regulators offer the intriguing possibility of de novo design – allowing...
There is growing evidence that growth with invasive species influences the traits of co-occurring native plants over multiple generations. Some studies indicate that these experienced populations perform better in the presence of the invasive species that led to the trait changes. These experienced populations could serve as source material for...
Metabolic conditions affect the developmental tempo of most animal species. Consequently, developmental gene regulatory networks (GRNs) must faithfully adjust their dynamics to a variable time scale. We find evidence that weak repressors of gene expression provide the necessary coupling between GRN output and cellular metabolism. Using a mathematical model that...