This work combines the use of high-throughput mass spectrometry with peptide arrays for to monitor reactions on peptides. The Mrksich lab introduced a high-throughput, label-free, biochemical assay that relies on self-assembled monolayers on gold and matrix-assisted laser desorption/ionization mass spectrometry, termed SAMDI-MS. This dissertation introduces new applications of SAMDI-MS and...
Functional electronic materials are difficult to design due to the complex interplay among chemistry, atomic structure, and electrical properties. This dilemma is further amplified in transition metal compounds which can defy the band-theory description of non-correlated electrons. Exploring the vast possible design space completely with experiments or first-principles simulations is...
International media immediately lambasted plans to build a Louvre and a Guggenheim museum in Abu Dhabi, United Arab Emirates (UAE) as the whimsy of wealthy sheikhs using oil money to “buy culture.” The museums are part of a $27b development project called Saadiyat Island. While Saadiyat is spectacular, dismissing it...
The development and use of organic anionic chromophores that absorb the entire visible spectrum & into the near-infrared region while providing highly reducing equivalents is pinnacle for artificial photosynthesis. This dissertation investigates the rational design of new donor-acceptor systems for artificial photosynthesis that couple naphthalene diimide (NDI)/perylene diimide (PDI) radical...
I. The distribution of tsunami amplitudes in the open ocean is controlled by source mechanism and bathymetry geometry. Although detailed studies have considered heterogeneity effects in earthquake tsunami sources, little or no attention has been paid to the effects of physical resolution of detailed bathymetry on tsunami waveforms in the...
The term Connected Vehicle (CV) is broadly used to identify any ‘smart vehicle’ with wireless connectivity to the roadside infrastructure and other vehicles. CVs with automation capabilities are called connected automated vehicles (CAVs). With real-time communication and data transmission capability, CAVs have the potential to improve the transportation system’s traffic...
“Speculative Justice” asks how U.S. terrorism cases with numerous indicators of entrapment prevail in federal court despite case law designed to prevent these very policing practices. Drawing on a combination of two case studies, an original archive of digital court filings from over 250 defendants, and a collection of over...
In the near future, self-driving or driverless vehicles will operate without human control, enabling passengers to use their time in new ways. This opens up avenues for designing new interactions and experiences for individuals or groups traveling in an automobile. For that scenario, automobile manufacturers propose developing bigger and better...
Surface-enhanced Raman scattering (SERS) spectroscopy has been demonstrated to be a powerful analytical tool. Its chemical specificity, rapidity, and portability make it an attractive technique for biosensing, but its application to this field has been limited by the fundamental distance dependence of the surface-enhancement effect. Many biological molecules of interest...
The presented thesis introduces our work of extending high-resolution x-ray 3D imaging towards extended samples. With the advent of x-ray sources with higher brightness and better coherence, as well as the rise of the needs to examine the fine structures of large objects in the field of materials science, biology,...