This dissertation focuses on quantifying protein folding stability determinants and presenting initial experiments that can guide the development of a novel assay that identifies cell-penetrating miniproteins. First, despite over a century of scholarship on protein folding stability, applying this knowledge to design proteins computationally remains limited. Usually, protein designers generate...
This dissertation focuses on quantifying protein folding stability determinants and presenting initial experiments that can guide the development of a novel assay that identifies cell-penetrating miniproteins. First, despite over a century of scholarship on protein folding stability, applying this knowledge to design proteins computationally remains limited. Usually, protein designers generate...
Objective: To evaluate patient-reported experiences of telehealth and disparities in access, use, and satisfaction with telehealth visits during the COVID-19 pandemic (aim 1), to evaluate prevalence of portal use pre-, peri-, and post-pandemic, among the C3 cohort, and investigate any disparities in use by sociodemographic factors (aim 2), and to...
Air pollution is a pervasive environmental issue that has significant impacts on human health. Urban areas are particularly susceptible to high levels of air pollution due to concentrated emissions and populations. Urban air pollution has been linked to a range of adverse health effects, including respiratory diseases, cardiovascular diseases,...
Equilibrium models of star formation successfully derive the globally-averaged Kennicutt-Schmidt (KS) relation, positing that star formation rates (SFRs) are self- regulated by the turbulence in the interstellar medium (ISM) generated by stellar feedback. However, these models make assumptions that may not be achieved in realistic galaxy systems. Cosmological zoom-in simulations,...
As sound changes advance across large geographic areas, they progress unevenly across populations. The speakers who lead these changes often share macro-social identities, like place or social class affiliations (e.g. Nesbitt 2018; Wagner et al. 2016). But the features undergoing these macro-level sound changes also hold social meanings related to...
Metaphor is an important and pervasive phenomenon in language and cognition. The vast majority of psycholinguistic research on metaphor has focused on noun metaphors (e.g., That surgeon is a butcher; That lawyer is a shark), while relatively little has investigated the processing of verb metaphors (e.g., The car limped down...
As our world is increasingly filled with data visualizations, having the skills to leverage data visualizations is essential for participation in society. Confident engagement with data visualizations is critical for being an educated member of society; however, research has shown that it is difficult for individuals to digest and gain...
Understanding the characteristics of interfaces between materials and solvent media such as structure, chemistry, and charge remains crucial to determining the properties and performance of numerous systems and technologies. This thesis focuses specifically on characterizing the interactions of water at oxide interfaces. A large collection of questions remains unanswered about...
Visual localization is a critical capability for autonomous systems, enabling them to accuratelyestimate their position and orientation within an environment using visual data. This thesis focuses
on achieving a robust and reliable visual localization on both local and global level to enhance
localization performance in a wide range of environments....