Northwestern University

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Deubiquitinases: Pro-oncogenic Activity and Therapeutic Targeting in Acute Leukemia

Description:

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease, affecting children and adults. Chemotherapy regimens show high response rates but have debilitating effects and carry risk of relapse. Until now, no targeted therapy has been approved. In addition, 40% of patients will relapse and their treatment options are limited because...

Keyword:

USP11, LCK, USP7, glucocorticoid, leukemia, and ubiquitination

Subject:

Molecular biology, Oncology, and Biochemistry

Creator:

Gutierrez Diaz, Blanca Teresa

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/02/2022

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_862777 and http://dissertations.umi.com/northwestern:15858