Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Circadian rhythms — physiological, behavioral, and metabolic oscillations with an approximate 24-h period — are controlled by an evolutionarily conserved set of core clock genes operating at the transcriptional and protein level. Entrainable by Zeitgebers (external environmental stimuli such as light, temperature, and food) that modulate time-of-day specific functions, the...
Keyword:: Differential Dynamics Detection, Time-Series Analysis, Dynamical Systems Theory, Circadian Rhythms, Topological Analysis, and Cycle Detection
Subject:: Biostatistics, Applied mathematics, and Bioinformatics
Creator:: Ness-Cohn, Elan Meir
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_875611 and http://dissertations.umi.com/northwestern:15905

Description:: In the short amount of time that genetic manipulation has been possible through CRISPR technology, myriad applications have been developed. Results from one of the most promising applications of this technology, pooled screens, have shown that single guide RNAs (sgRNAs), RNA sequences used to target specific regions of the genome,...
Keyword:: sgRNA design, CRISPR efficiency, and Machine learning
Subject:: Biostatistics, Statistics, and Bioinformatics
Creator:: Zarate, Oscar Alberto
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15353 and etdadmin_upload_773909

Description:: The advent of sequencing technologies has generated a large amount of biological and medical data. These data such as genetic sequencing data and lab experimental evidence data can help understand critical biomedical problems. This dissertation makes contribution in three different but related applications in biomedical research. In Chapter 2, we...
Keyword:: Normalization, Metagenomics, Graph neural network, Clustering, and Differential abundance test
Subject:: Biostatistics, Statistics, and Bioinformatics
Creator:: Ma, Yuanjing
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 01/21/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15057 and etdadmin_upload_736532

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