Northwestern University

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Quantitative and Multiplexed Chemical-Genetic Phenotyping Reveals the Architecture of the Proteostasis Network in Breast Cancer

Description:

The protein homeostasis (proteostasis) network, a critical cytoprotective system that restores homeostasis in response to molecular stress, comprises distinct pathways, including the heat-shock response, unfolded protein response, oxidative stress response, and autophagy. These distinct pathways are all co-opted by tumor cells to cope with cancer-associated stress, and their activation in...

Subject:

Pharmacology, Genetics, and Biology

Creator:

Brockway, Sonia Susan

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_780926 and http://dissertations.umi.com/northwestern:15412