Index Catalog // Arch : Northwestern University Institutional Repository

1. The circadian clock generates anticipatory insulin secretory cycles by regulating β-cell enhancers

Description:: The circadian clock is a biological oscillator present in all terrestrial life forms that aligns organismal functions with the daily rising and setting of the sun. In mammals clocks are expressed both in pacemaker cells in the brain that are directly entrained by light as well as in all peripheral...
Keyword:: Pancreatic beta cell, Genomics, Diabetes, and Circadian rhythm
Subject:: Interdepartmental Biological Sciences (IBiS) Graduate Program
Creator:: Mark Perelis
Owner:: Scholarly Digital Publishing
Date Uploaded:: 02/20/2018
Date Modified:: 02/20/2018
Date Created:: 2016-01-01
Resource Type:: Dissertation

2. Interrogation of the Proteoform Landscape of Immune Activation after Organ Transplantation: Translational Top-Down Proteomics for Next-Generation Diagnostics and Personalized Medicine

Description:: What follows is a strictly post-genomic dissertation. Over the past five years, I have strived to leave the nucleus behind, and even the endoplasmic reticulum and golgi apparatus. The human genome was sequenced over 15 years before the submission of this document, and the world changed somewhat less than anticipated—besides...
Keyword:: Top-Down Proteomics, Proteomics, Transplantation, Immunology, Mass Spectrometry, and Proteoforms
Subject:: Interdepartmental Biological Sciences (IBiS) Graduate Program
Creator:: Tinothy Toby
Owner:: Scholarly Digital Publishing
Date Uploaded:: 01/25/2019
Date Modified:: 01/25/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

3. Characterization and Applications of Natural Variation in C. elegans

Description:: Caenorhabditis elegans has been a highly productive model organism. However, most of the knowledge gained from the species has come a single strain isolated in Bristol, England in 1951. However, there exists significant potential in the natural variation present in the species to make discoveries. In this dissertation, I describe...
Keyword:: natural variation, pot-2, C. elegans, genomics, and telomeres
Subject:: Interdepartmental Biological Sciences (IBiS) Graduate Program
Creator:: Daniel Elwood Cook
Owner:: Scholarly Digital Publishing
Date Uploaded:: 11/18/2019
Date Modified:: 11/18/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

4. Regulation of Anaphase Progression during Caenorhabditis elegans Oocyte Meiosis

Description:: Meiosis is a specialized form of cell division where chromosomes are duplicated once and segregated twice, in order to reduce the chromosome number by half to generate haploid gametes. In contrast to mitosis, oocyte meiosis in many species occurs in the absence of centrosomes, the microtubule organizing centers that nucleate...
Keyword:: Biology
Subject:: Interdepartmental Biological Sciences (IBiS) Graduate Program
Creator:: Amanda Cara Roca
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/28/2019
Date Modified:: 10/28/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

5. Chromatin Scaling and the Regulation of Cellular Function

Description:: Chromatin organization involves a hierarchy of length scales ranging from a few tens of nanometers in nucleosomes to hundreds of nanometers for chromosomal territories. This physical nanostructure is regulated by the genetic code, differential methylation and histone modifications that comprise the histone code, as well as non-molecular factors, such as...
Keyword:: Physicochemical, Nanoscale, Chromatin, and Transcription
Subject:: Interdepartmental Biological Sciences (IBiS) Graduate Program
Creator:: Greta Mary Wodarcyk
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/14/2019
Date Modified:: 10/14/2019
Resource Type:: Dissertation

6. The Role of FGF Signaling in the Regulation of Pluripotency and Neural Crest Formation

Description:: The neural crest is a unique, vertebrate specific stem cell population that gives rise to a diverse set of derivatives in the embryo, including sensory neurons, glial cells, melanocytes, and craniofacial structures such as cartilage, bone, and connective tissue. Unlike other multipotent stem cell populations present at this time, neural...
Keyword:: Pluripotency, Cell Signaling, FGF Signaling, Stem Cells, and Neural Crest
Subject:: Interdepartmental Biological Sciences (IBiS) Graduate Program
Creator:: Lauren Geary Bowman
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/22/2019
Date Modified:: 04/22/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

7. Regulation of Ovarian Granulosa Cell Proliferation and Differentiation by the Notch Signaling Pathway

Description:: The follicle is the functional unit of the mammalian ovary and serves as a tightly controlled microenvironment where granulosa cells nurture the growth and maturation of the oocyte. Early events in follicular development are autonomous of the hypothalamic-pituitary-gonadal axis and are instead controlled by local factors that are used in...
Keyword:: Granulosa cells, Notch pathway, Ovary, and Follicle
Subject:: Interdepartmental Biological Sciences (IBiS) Graduate Program
Creator:: Rexxi Diptya Prasasya
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/01/2019
Date Modified:: 04/01/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

8. Investigations into the role of zinc regulation in germline development in Caenorhabditis elegans

Description:: The purpose of the egg is to give rise to offspring in sexually reproducing organisms. Zinc thresholds became connected to egg quality from initial breakthrough discoveries in M. musculus which demonstrated that large-scale zinc fluxes occur during meiotic maturation, and these fluxes are required to maintain female egg viability. Numerous...
Keyword:: germline regulation, zinc, zinc flux, and oocyte maturation
Subject:: Interdepartmental Biological Sciences (IBiS) Graduate Program
Creator:: Adelita D. Mendoza
Owner:: Scholarly Digital Publishing
Date Uploaded:: 02/11/2019
Date Modified:: 02/11/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

9. The Mechanism, Adaptive Fitness, and Evolution of Galactose Induced Transcriptional Memory in Saccharomyces cerevisiae

Description:: Certain inducible genes show faster reactivation if they were recently expressed. This epigenetic phenomenon is called transcriptional memory and is inherited for several generations after the first round of induction. During this phase, genes show several conserved molecular features that are essential for faster reactivation: peripheral localization of the gene,...
Keyword:: Epigenetic memory, Adaptive fitness, Genome organization, Evolution, Gene regulation, and GAL genes
Subject:: Interdepartmental Biological Sciences (IBiS) Graduate Program
Creator:: Varun Sood
Owner:: Scholarly Digital Publishing
Date Uploaded:: 01/11/2019
Date Modified:: 01/11/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

10. Microprocessor Recruitment to RNA Polymerase II is Required for Differential Expression of MicroRNAs

Description:: The cellular abundance of mature microRNAs (miRNAs) is dictated by the efficiency of nuclear processing of primary miRNA transcripts (pri-miRNAs) into pre-miRNA intermediates. The Microprocessor complex, composed of Drosha and DGCR8 carries this out, but it has been unclear what controls Microprocessor's differential processing of various pri-miRNAs. Here, I show...
Keyword:: Molecular Biology
Subject:: Interdepartmental Biological Sciences (IBiS) Graduate Program
Creator:: Victoria Anne Church
Owner:: Scholarly Digital Publishing
Date Uploaded:: 01/09/2019
Date Modified:: 01/29/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

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1. The circadian clock generates anticipatory insulin secretory cycles by regulating β-cell enhancers

2. Interrogation of the Proteoform Landscape of Immune Activation after Organ Transplantation: Translational Top-Down Proteomics for Next-Generation Diagnostics and Personalized Medicine

3. Characterization and Applications of Natural Variation in C. elegans

4. Regulation of Anaphase Progression during Caenorhabditis elegans Oocyte Meiosis

5. Chromatin Scaling and the Regulation of Cellular Function

6. The Role of FGF Signaling in the Regulation of Pluripotency and Neural Crest Formation

7. Regulation of Ovarian Granulosa Cell Proliferation and Differentiation by the Notch Signaling Pathway

8. Investigations into the role of zinc regulation in germline development in Caenorhabditis elegans

9. The Mechanism, Adaptive Fitness, and Evolution of Galactose Induced Transcriptional Memory in Saccharomyces cerevisiae

10. Microprocessor Recruitment to RNA Polymerase II is Required for Differential Expression of MicroRNAs

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1. The circadian clock generates anticipatory insulin secretory cycles by regulating β-cell enhancers

2. Interrogation of the Proteoform Landscape of Immune Activation after Organ Transplantation: Translational Top-Down Proteomics for Next-Generation Diagnostics and Personalized Medicine

3. Characterization and Applications of Natural Variation in C. elegans

4. Regulation of Anaphase Progression during Caenorhabditis elegans Oocyte Meiosis

5. Chromatin Scaling and the Regulation of Cellular Function

6. The Role of FGF Signaling in the Regulation of Pluripotency and Neural Crest Formation

7. Regulation of Ovarian Granulosa Cell Proliferation and Differentiation by the Notch Signaling Pathway

8. Investigations into the role of zinc regulation in germline development in Caenorhabditis elegans

9. The Mechanism, Adaptive Fitness, and Evolution of Galactose Induced Transcriptional Memory in Saccharomyces cerevisiae

10. Microprocessor Recruitment to RNA Polymerase II is Required for Differential Expression of MicroRNAs