The aviation industry is set to see another significant leap in new technology, namely electric aircraft. As of the time of this research, both 9-seat and 19-seat aircraft would be ready to be launched by air service providers under the Essential Air Service (EAS) program. While electric aircraft manufacturers are...
Lack of access to safe drinking water is a global problem, and methods to reliably and easily detect contaminants could be transformative. We report the development of a cell-free in vitro transcription system that uses RNA Output Sensors Activated by Ligand Induction (ROSALIND) to detect contaminants in water. A combination...
Within the world of art music, composers have employed a variety of techniques to infuse popular music elements into their writing. This document is an examination of specific instances of this trend in twenty-first century wind ensemble repertoire. The study is limited to twenty-first century wind ensemble works by living...
The 2005 NHL Lockout instituted a hard salary cap, which is the most limiting salary cap of the major US sports leagues. The NHL as a result doesn’t have the luxury of overpaying or dumping a contract as other professional sports leagues have, which places a huge constraint and emphasis...
This study is in consideration of the spread of COVID-19, the related various government responses, and how these responses and other demographic variables affected the spread and severity of the virus on a domestic (United States) and international level. During the last few months, the virus has spread from its...
Advances in biosensor engineering have enabled the design of programmable molecular systems to detect a range of pathogens, nucleic acids, and chemicals. Here, we engineer and field-test a biosensor for fluoride, a major groundwater contaminant of global concern. The sensor consists of a cell-free system containing a DNA template that...
In May 2018, the US Food and Drug Administration approved daily oral pre-exposure prophylaxis (PrEP) for adolescents under age 18. Although this is an important step toward HIV prevention for adolescents assigned male at birth who have sex with males (AMSM), limited research exists to gauge their awareness of PrEP...
The focus of this thesis is the design of non-natural molecules for use in biological applications. Chapter one details a strategy to use small molecules to reactivate mutated p53, an oncoprotein that is prevalent in several types of cancer, back to its wild-type function. Wild-type p53 has the ability to...
Evidence suggests both that teacher quality matters for students' outcomes and that principals might not hire the "best" teachers. However, relatively little is known about what characteristics principals value in teachers or how they make hiring decisions. In my dissertation, I use a diverse array of data sources to examine...