Second harmonic generation (SHG),
a nonlinear optical tool, was used to
characterize DNA bound through a
chemical linker to the flat surface of a
hemispherical lens. Contact angle
measurements were used to guarantee
that the chemical linker did not hydrolyze
under experimental conditions. SHG
experiments followed the effects of salt...
HspB2 was discovered as a chaperone of muscular dystrophy protein kinase (DMPK) and originally named, DMPK binding protein (MKBP) and presently called HspB2. Functionally, MKBP binds to DMPK and stabilizes its kinase activity, thereby accelerating the progression of muscular dystrophy. Although other binding partners of HspB2 have been found, the...
Packaging of DNA into nucleosomes and chromatin not only enables DNA to fit within the nucleus, but it also protects and organizes DNA. However, the wrapping of DNA around histones occludes DNA from binding proteins in solution. Proteins that regulate, express and repair DNA are able to function only when...
This study investigates the nature of the face-to-face interactions and collaborations between secondary school students and community members in the nested contexts of the classroom and a local Italian community, both situated in a large city in Canada. Students used the tools of inquiry of cultural ethnographers, interviewing members of...
Because soft materials, particularly polymer gels, are playing a greater role in industrial and biotechnological applications today, the exploration of their mechanical behavior over a range of deformations is becoming more relevant in our daily lives. Understanding these properties is therefore necessary as a means to predict their response for...
This dissertation argues that the National Science Foundation's role in, and influence on, the development of large scale scientific and technological systems, most notably improvements to U.S. information infrastructure, can best be understood through an examination of the NSF's institutional history. Because of the Foundation's weakened starting position at its...
Micro/nanoscale friction behavior has drawn a great deal of attention because it can reveal friction behavior at the interface level and ultimately lead to the discovery of the origin or real mechanism of friction. Surface wettability is an important property of solid surfaces and has been widely used in fundamental...
This thesis deals with three problems encountered in micro- and nano-fluidics: linear stability analysis of electrokinetic mixing in icrochannels, development of a general purpose numerical technique for fully resolved simulation of electrohydrodynamic particulate flows, and studying the phenomenon of molecular scale slip next to boundaries in micro- and nano-channels.
Mixing...
The de novo design of bio-inspired materials with precisely controlled properties is challenging, but has potential applications in nano-biotechnology. Applications range from nanometer scaled assemblies to three-dimensional scaffolds for tissue engineering. Genetic engineering of protein-based polymers offers distinct advantages over traditionally synthesized polymers, de novo proteins can be produced with...
My submission is a data dashboard that depicts global trends for new and total COVID-19 cases between Jan 01, 2020 and March 08, 2021. It contains two tabs (new and total cases) with three interactive visualizations. Two maps, an original and a log-scale-filled, show the number of new COVID-19 cases...
