Optical coherence tomography (OCT) is a high-resolution, non-contact, three-dimensional imaging technique, which has revolutionized the diagnosis and treatment of retinal diseases. Visible-light OCT (vis-OCT) extends OCT by enabling retinal oximetry – the measurement of oxygen saturation of hemoglobin from within individual retinal blood vessels. Three advances in the vis-OCT technique are presented: an improved vis-OCT oximetry method based on circumpapillary scan and graph-search segmentation; the calibration, simulation, and correction of spectroscopic sensitivity rolloff for vis-OCT oximetry; and the measurement of the inner retinal oxygen metabolism in the 50/10 oxygen-induced retinopathy model, an animal model for human retinopathy of prematurity. Optical coherence tomography angiography (OCTA) is another functional extension of OCT, which provides three-dimensional, non-invasive, capillary-level mapping of vascular perfusion. Two studies of OCTA in animal models are described: the monitoring of retinal vascular occlusions produced by imaging-guided laser photocoagulation; and the monitoring of laser-induced choroidal neovascularization, a model of wet age-related macular degeneration. Whether by providing insight into disease mechanisms or by directly imaging functional biomarkers in the human retina, vis-OCT oximetry and OCTA will be instrumental in preventing blindness for those suffering from vision-threatening disease.

Creator

• Soetikno, Brian

DOI

• https://doi.org/10.21985/n2-gc1k-8m06

Subject

• Physiology
• Ophthalmology
• Optics

Language

• en

Alternate Identifier

• etdadmin_upload_625515
• http://dissertations.umi.com/northwestern:14438

Keyword

• ophthalmology
• imaging
• blood flow
• retina
• oxygen saturation
• optical coherence tomography

Date created

• 2018-01-01

Resource type

• Dissertation

Rights statement

• In Copyright