Episodic memory provides a means by which we reflect on the past, make decisions about the future, and form a learned identity. Episodic memory depends on the hippocampus as well as on the distributed set of regions that form a hippocampal-cortical network (HCN), including medial prefrontal, posterior cingulate, and medial and lateral parieto-occipital cortex. While connectivity of this network is primarily measured in the absence of a task, there is preliminary evidence that functional connectivity patterns within the HCN can vary depending on cognitive demands. The goal of this thesis work was to examine the functional relevance of changes in network connectivity related to memory processing. Our laboratory has successfully shown that noninvasive brain stimulation individualized to target each subject’s HCN can increase the resting-state connectivity of the network and improve episodic memory. We therefore used this technique to assess whether we could manipulate memory-related connectivity patterns and thus causally test their relationship to memory processing.

Creator

• Warren, Kristen N

DOI

• https://doi.org/10.21985/n2-j5dt-yv47

Subject

• Neurosciences

Language

• en

Alternate Identifier

• http://dissertations.umi.com/northwestern:14985
• etdadmin_upload_717587

Keyword

• memory
• hippocampus
• brain network
• stimulation

Date created

• 2020-01-01

Resource type

• Dissertation

Rights statement

• In Copyright